On KZFPs:
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB domain and a C-terminal array of DNA-binding zinc fingers, they participate, together with their co-factor KAP1 (also known as TRIM28), in repression of sequences derived from transposable elements (TEs).
The data you can find in the KRABopedia:
For each KZFP, we provide:
- The binding obtained from ChIP-exo and/or ChIP-seq experiments.
- The interaction with other proteins obtained from mass spectometry experiments.
- The level of polymorphism in human population with the data of the gnomAD project.
- The age determined by the furthest ancestor were the sequence was found.
- The motif obtained from cisBP.
- The level of expression in human healthy tissues obtained from the GTEx project.
- All data can be navigated or downloaded.
- The human reference genome used in all analysis is hg19 (GHRC37).