The KRABopedia is an effort from the Tronolab to collate KRAB zinc finger protein data and make it easily accessible. The Tronolab is part of the Life Sciences section of EPFL, Switzerland.

On KZFPs:
Krüppel-associated box domain zinc finger proteins (KRAB-ZFPs) are the largest family of transcriptional regulators in higher vertebrates. Characterized by an N-terminal KRAB domain and a C-terminal array of DNA-binding zinc fingers, they participate, together with their co-factor KAP1 (also known as TRIM28), in repression of sequences derived from transposable elements (TEs).

The data you can find in the KRABopedia:
For each KZFP, we provide:
  • The binding obtained from ChIP-exo and/or ChIP-seq experiments.
  • The interaction with other proteins obtained from mass spectometry experiments.
  • The level of polymorphism in human population with the data of the gnomAD project.
  • The age determined by the furthest ancestor were the sequence was found.
  • The motif obtained from cisBP.
  • The level of expression in human healthy tissues obtained from the GTEx project.
  • All data can be navigated or downloaded.
  • The human reference genome used in all analysis is hg19 (GHRC37).