KRABopedia - The place to find Krab Zinc Finger information

<u>Section list:</u> <ul> <li><a href='#General'>General</a></li> <li><a href='#Polymorphism'>Polymorphism</a></li> <li><a href='#Expression in tissues (from GTEx)'>Expression in tissues (from GTEx)</a></li> <li><a href='#CisBP motifs'>CisBP motifs</a></li> <li><a href='#ZFP'>Zinc Finger Print alignment</a></li> </ul> ------ <h2 id='General'>General</h2> | | | |--|--| | <b>Gene ensembl <br><i>Link to the corresponding Ensembl site</i></b> | <a href="http://www.ensembl.org/Multi/Search/Results?q=ENSG00000169981;site=ensembl~">ENSG00000169981</a> | | <b>Age (years) <br><i>Estimated age of the KRAB-ZNF as in <a href="https://pubmed.ncbi.nlm.nih.gov/28273063/">Imbeault et al</a></i></b> | 105 | | <b>Age (species) <br><i>The name of the species where the KRAB-ZNF was first observed as in <a href="https://pubmed.ncbi.nlm.nih.gov/28273063/">Imbeault et al</a></i></b> | Cape golden mole | | <b>\#peaks in exo <br><i>Number of peaks found in the ChIP-exo dataset</i></b> | | | <b>Incomplete KRAB domain</b> | | | <b>Interacts with K1</b> | Not in database | | <b>Interacts with</b> | Not in database | | <b>ORF sequence</b> | | | <b>Zinc fingers</b> | 11 | <div class="adroite"><a href="#"><b>back to top</b></a></div> ------ <h2 id='Polymorphism'>Polymorphism</h2> <table> <tr><th>gnomAD genome</th><th>gnomAD exome</th></tr> <tr><td><table></table> | Region | #miss.SNP x Kb | |--|--| | Exon | 63.51 | | Exon (no domain, nor Zfinger) | 63.51 | | Krab domain | NA | | Zinc finger | 48.748 | | Region | #miss.SNP | |--|--| | Zinc finger | 19 | | C2H2 | 2 | | Zinc finger print | 1 | <input type="button" id="button" style="float:left" value="[+] Help" onclick="afficher()" /><br> <form id="doc" style="display: none;"> <br>Gene view with all variants found at the gene of interest (canonical transcript).<br><ul><li> blue dots: synonymous & noncoding variants.</li><li> red dots: missense variants.</li><li> orange dots: splice variants.</li><li> green dots: Loss of function variants (frameshift, stop_lost or stop_gained mutation).</li><li> GERP score: a conservation score widely used to look at constraint across genes and non-coding regions, and also used in the best pathogenic variant scoring softwares. A score above 2 is considered conserved.</li><li> Green boxes on the genes: the exons.</li><li> Red boxes: the KRAB domain.</li><li> Blue boxes: the zinc finger domains.</li><li> Pink boxes: degenerate zinc finger domains.</li></ul> </form><br> <a href='../MAF_gnomAD/ZNF35.pdf'> <img src="../MAF_gnomAD/MAF_gnomAD/ZNF35.png" width="400" height="200" /> </a> <input type="button" id="button_2" style="float:left" value="[+] Help" onclick="afficher_2()" /><br> <form id="doc_2" style="display: none;"> <br>Zoomed plot of variants in each zinc finger domain with the specific amino acids plotted.<ul><li>blue dots: synonymous & noncoding variants.</li><li>red dots: missense variants.</li><li>orange dots: splice variants.</li><li>green dots: Loss of function variants (frameshift, stop_lost or stop_gained mutation).</li><li> Blue boxes: The positions of the DNA contacting amino acids</li><li> Red boxes: The Cytidine and Histidine amino acid positions</li></ul> </form><br> <a href='../Zfinger_gnomAD/ZNF35.pdf'> <img src="../Zfinger_gnomAD/Zfinger_gnomAD/ZNF35.png" width="400" height="200" /> </a> </td><td><table></table> | Region | #miss.SNP x Kb | |--|--| | Exon | 125.517 | | Exon (no domain, nor Zfinger) | 125.517 | | Krab domain | NA | | Zinc finger | 197.628 | | Region | #miss.SNP | |--|--| | Zinc finger | 94 | | C2H2 | 7 | | Zinc finger print | 16 | <input type="button" id="button1" style="float:left" value="[+] Help" onclick="afficher1()" /><br> <form id="doc1" style="display: none;"> <br>Gene view with all variants found at the gene of interest (canonical transcript).<br><ul><li> blue dots: synonymous & noncoding variants.</li><li> red dots: missense variants.</li><li> orange dots: splice variants.</li><li> green dots: Loss of function variants (frameshift, stop_lost or stop_gained mutation).</li><li> GERP score: a conservation score widely used to look at constraint across genes and non-coding regions, and also used in the best pathogenic variant scoring softwares. A score above 2 is considered conserved.</li><li> Green boxes on the genes: the exons.</li><li> Red boxes: the KRAB domain.</li><li> Blue boxes: the zinc finger domains.</li><li> Pink boxes: degenerate zinc finger domains.</li></ul> </form><br> <a href='../MAF_gnomAD_exome/ZNF35.pdf'> <img src="../MAF_gnomAD_exome/MAF_gnomAD_exome/ZNF35.png" width="400" height="200" /> </a> <input type="button" id="button2" style="float:left" value="[+] Help" onclick="afficher2()" /><br> <form id="doc2" style="display: none;"> <br>Zoomed plot of variants in each zinc finger domain with the specific amino acids plotted.<ul><li>blue dots: synonymous & noncoding variants.</li><li>red dots: missense variants.</li><li>orange dots: splice variants.</li><li>green dots: Loss of function variants (frameshift, stop_lost or stop_gained mutation).</li><li> Blue boxes: The positions of the DNA contacting amino acids</li><li> Red boxes: The Cytidine and Histidine amino acid positions</li></ul> </form><br> <a href='../Zfinger_gnomAD_exome/ZNF35.pdf'> <img src="../Zfinger_gnomAD_exome/Zfinger_gnomAD_exome/ZNF35.png" width="400" height="200" /> </a> </td></tr> </table> <div class="adroite"><a href="#"><b>back to top</b></a></div> ------ <h2 id='Expression in tissues (from GTEx)'>Expression in tissues (from GTEx)</h2> <input type="button" id="GTX_button" style="float:left" value="Open Expression Information from GTEx Website" onclick="document.location.href='https://www.gtexportal.org/home/gene/ZNF35'" /><br><br> <div class="adroite"><a href="#"><b>back to top</b></a></div> ------ <h2 id='CisBP motifs'>CisBP motifs</h2> <input type="button" id="CisBP_button" style="float:left" value="Open CisBP Website" onclick="document.location.href='http://cisbp.ccbr.utoronto.ca'" /><br><br> <table> <tr><th>Forward</th><th>Reverse</th></tr> <tr><td> <tr><td><table><tr><th> ENSEMBL ID </th><td> ENSG00000169981 </td></tr><tr><th> Motif_ID </th><td> M08250_2.00 </td></tr><tr><th> Motif_Type </th><td> ChIP-seq </td></tr><tr><th> MSource_Identifier </th><td> Najafabadi2015b </td></tr><tr><th> Study_ID </th><td> ZNF35 </td></tr><tr><th> Author_Year </th><td> Najafabadi_2015b </td></tr><tr><th> PMID </th><td> 25690854 </td></tr><tr><th> TF_Status </th><td> D </td></tr></table><a href="../logos_kzfp/M08250_2.00_fwd.png"><img src="../logos_kzfp/M08250_2.00_fwd.png" width="200" height="100"></td> <td><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><a href="../logos_kzfp/M08250_2.00_rev.png"><img src="../logos_kzfp/M08250_2.00_rev.png" width="200" height="100"></td></tr> <tr><td><table><tr><th> ENSEMBL ID </th><td> ENSG00000169981 </td></tr><tr><th> Motif_ID </th><td> M08334_2.00 </td></tr><tr><th> Motif_Type </th><td> ChIP-seq </td></tr><tr><th> MSource_Identifier </th><td> Schmitges2016 </td></tr><tr><th> Study_ID </th><td> P13682_1-10.RCADE </td></tr><tr><th> Author_Year </th><td> Schmitges_2016 </td></tr><tr><th> PMID </th><td> 27852650 </td></tr><tr><th> TF_Status </th><td> D </td></tr></table><a href="../logos_kzfp/M08334_2.00_fwd.png"><img src="../logos_kzfp/M08334_2.00_fwd.png" width="200" height="100"></td> <td><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><br><a href="../logos_kzfp/M08334_2.00_rev.png"><img src="../logos_kzfp/M08334_2.00_rev.png" width="200" height="100"></td></tr> </td></tr> </table> <div class="adroite"><a href="#"><b>back to top</b></a></div> ------ <h2 id="ZFP">ZFP alignment</h2> <input type="button" id="button_zfp" style="float:left" value="[+] Help" onclick="afficher_zfp()"/><br> <form id="doc_zfp" style="display: none;"> <br>Zinc Finger Print alignment of the ZFP of interest against all other ZFPs </form> <a href="../ZFP_CAZF_score/ZNF35.pdf"> <img src="../ZFP_CAZF_score/pngs/plotzfp_ZNF35.png" width="400" height="200" /> </a> <table> <tr> <td></td> <td>GeneName1</td> <td>KZFP1</td> <td>GeneName2</td> <td>KZFP2</td> <td>CAZF_score</td> </tr> <tr> <td>146279</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF182</td> <td>NC_000023.10_RF_OOFZFA_508</td> <td>0.174293785310734</td> </tr> <tr> <td>146393</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF182</td> <td>NW_004070880.2_RF_OOFZFA_5</td> <td>0.174293785310734</td> </tr> <tr> <td>146104</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF320</td> <td>NC_000019.9_RF_OOFZFA_478</td> <td>0.172021419009371</td> </tr> <tr> <td>146262</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF674</td> <td>NC_000023.10_RF_OOFZFA_499</td> <td>0.170013386880857</td> </tr> <tr> <td>146065</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF285</td> <td>NC_000019.9_RF_OOFZFA_443</td> <td>0.169433288710397</td> </tr> <tr> <td>146102</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF468</td> <td>NC_000019.9_RF_OOFZFA_476</td> <td>0.154581591672814</td> </tr> <tr> <td>146063</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF235</td> <td>NC_000019.9_RF_OOFZFA_441</td> <td>0.139767402945114</td> </tr> <tr> <td>146050</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF45</td> <td>NC_000019.9_RF_OOFZFA_439</td> <td>0.137006358768407</td> </tr> <tr> <td>145637</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF239</td> <td>NC_000010.10_RF_OOFZFA_430</td> <td>0.13637157324952</td> </tr> <tr> <td>146084</td> <td>ZNF35</td> <td>NC_000003.11_FF_OOFZFA_106</td> <td>ZNF616</td> <td>NC_000019.9_RF_OOFZFA_467</td> <td>0.125194394599675</td> </tr> </table> <input type="button" id="button_csv" style="float:left" value="Open full table" onclick="document.location.href='../ZFP_CAZF_score/csv/ZNF35.xlsx'" /><br> <div class="adroite"><a href="#"><b>back to top</b></a></div>